This manual provides a route for all methodological approaches and statistical techniques applicable to the analysis of survival, focusing on the study of relative survival. The biggest advantage of relative survival is that information is not required on the occurrence of the phenomenon of interest, providing a measure of excess occurrence regardless of whether this excess is directly or indirectly attributable to the problem under study. An innovation that makes this handbook is the introduction to the study of models for estimating the geographical variability of survival rates and their application to spatial epidemiology. nIt is also interesting to emphasize that the purpose of illustrating the methods and allow the reader to a reproduction of the results, a final chapter devoted to the application of the methods to the analysis of the geographical variability of the relative survival of cancer Breast Health Region Girona (RSG), providing all necessary instructions for the proper management of data files.