After taking fertility drugs, Manda Frank gives birth to 11 babies in a Virginia town. At the same time, a dairy farmer named Margaret Prickett has a plan to transport a 1200-pound cheese to the White House (based on an incident from the presidency of Thomas Jefferson). Other characters include an insincere presidential candidate, a Jefferson-impersonator in love with Margaret, his selfless minister father, and a teenager madly in love with her history teacher.