Buried deep within a jungle, ancient ruins conceal a deadly secret… Buried in a tomb in Venice, a great explorer hides a truth that could shatter history… Buried in our own genetic code, a mystery like no other… But nothing stays buried forever - and it will be up to Sigma Force to face what will be unearthed: a plague beyond any cure, a scourge that turns all of Nature against mankind. From the high seas of the Indian Ocean to the dark jungles of Southeast Asia, from the canals of Venice to the crypts of ancient kings, Sigma Force must piece together a mystery that, unless solved, will end all life on our planet. But even this challenge may prove too large for Sigma Force alone. With a worldwide pandemic growing, Painter Crowe and Commander Gray Pierce turn to their deadliest adversaries for help, teaming up with a diabolical foe who thwarted them in the past. But can the enemy be trusted even now? Or will they prove to be another Judas...?